Regrettably, a lot of the titles I'd find most offensive actually do exist in one form another, especially if you include freeware (i.e. "Ethnic Cleansing," "KZ Manager," and "Super Columbine Massacre RPG"). Here are a few others I hope we don't see:
SimCubicle
Custer's Return
The Straight Story Video Game - based on the movie
The Real Slim Shady's <Anything>
Mario's Adventures in Plumbing - on a side note, why does every RPG have to have sewer levels?
Celebrity Fit Club: The Video Game - watch your character lose weight while you sit there eating cheetos
Emoquest - sort of like the Sims, but the objective is to keep your mood down, not eat, not work, etc.