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Rookie quarterback Eli Manning will make his first professional start when the Giants play the defending NFC champion Panthers in a preseason game Thursday.
Giants coach Tom Coughlin made the announcement Tuesday.
Manning is competing with veteran Kurt Warner for the starting job. Warner started last week's 34-24 victory over Kansas City.
"It's Eli's turn. Eli will go. He will start," Coughlin said. "The decision coming in is that they will compete for the job, and so therefore we're going to give them the opportunity for both of them to have a start. And this is Eli's opportunity.